Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts.

Shuo Xu,Qihui Zhou,Chun Fan,Hongmei Zhao,Yanwen Wang,Xiaohui Qiu,Kai Yang,Qiuxia Ji

Archives of Oral Biology（2019）

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摘要

•P. gingivalis-LPS alone could not activate the NLRP3 inflammasome in HGFs.•P. gingivalis-LPS + ATP activates NLRP3 inflammasome in HGFs.•Dox inhibited the activation of NLRP3 inflammasome in HGFs.•Dox reduces the expression of IL-1β by inhibiting the NLRP3 inflammasome.

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关键词

Doxycycline,P. gingivalis-LPS,Adenosine triphosphate,NLRP3 inflammasome,IL-1β,Periodontitis

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