Targeting CDK9 and MCL-1 by a new CDK9/p-TEFb inhibitor with and without 5-fluorouracil in esophageal adenocarcinoma.

Zhimin Tong,Alicia Mejia,Omkara Veeranki,Anuj Verma,Arlene M Correa,Rashmi Dokey,Viren Patel,Luisa Maren Solis,Barbara Mino, Riham Kathkuda,Jaime Rodriguez-Canales,Steven H Lin,Sunil Krishnan,Scott Kopetz,Mariela Blum,Jaffer A Ajani,Wayne L Hofstetter,Dipen M Maru

CANCER RESEARCH（2019）

引用 11|浏览60

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摘要

BAY1143572 and 5-FU have synergistic antitumorigenic effects against EAC. MCL-1 is a downstream target of CDK9 inhibitors and a predictor of response to neoadjuvant chemoradiation in EAC.

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关键词

5-fluorouracil and MCL-1,CDK9,adenocarcinoma,esophagus

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