Nkx2.5 Based Ventricular Programming of Murine ESC-Derived Cardiomyocytes.

Frauke Thiele, Christin Voelkner,Vivien Krebs,Paula Müller, Julia Jeannine Jung,Christian Rimmbach,Gustav Steinhoff,Thomas Noack,Robert David,Heiko Lemcke

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology（2019）

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摘要

Therefore, we demonstrate cardiovascular subtype forward programming of ESCs using a combination of transcription factors along with small molecule administration. However, our findings also underline current assumptions, that a terminal maturation of PSC derived cardiomyocytes in vitro is still an unsolved problem which urgently needs to be addressed in the field.

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关键词

Cardiovascular forward programming,Nkx2.5,PSCs,Ventricular subtype identity

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