Whole-Exome and RNA-Sequencing Analyses of Acinic Cell Carcinomas of the Breast.

Francisco Beca,Simon S K Lee,Fresia Pareja,Arnaud da Cruz Paula,Pier Selenica,Lorenzo Ferrando,Rodrigo Gularte-Merida,Hannah Y Wen,Hong Zhang,Elena Guerini-Rocco,Emad A Rakha,Britta Weigelt,Jorge S Reis-Filho

CANCER RESEARCH（2020）

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摘要

No pathognomonic genetic alterations were detected in the ACCs analyzed. These tumors have somatic genetic alterations similar to those of common forms of TNBC and may display HR deficiency or microsatellite instability. These findings provide further insights as to why ACCs which are usually clinically indolent may evolve into or in parallel with high-grade TNBC. This article is protected by copyright. All rights reserved.

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关键词

DNA damage repair,acinic cell carcinoma,breast cancer,massively parallel sequencing

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