ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy

Yuan Tian
Yuan Tian
Bin Yang
Bin Yang
Weinan Qiu
Weinan Qiu
Yajing Hao
Yajing Hao
Zhenxing Zhang
Zhenxing Zhang
Zhangjun Lin
Zhangjun Lin
Otto K W Cheung
Otto K W Cheung
Weiqin Yang
Weiqin Yang

Nature communications, pp. 3391-16, 2019.

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Abstract:

Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome that elevates the risk of hepatocellular carcinoma (HCC). Although alteration of lipid metabolism has been increasingly recognized as a hallmark of cancer cells, the deregulated metabolic modulation of HCC cells in the NAFLD progression remain...More

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