Risk of Premature Atherosclerotic Disease in Patients With Monogenic Versus Polygenic Familial Hypercholesterolemia.
Journal of the American College of Cardiology(2019)
摘要
Patients with monogenic FH and superimposed elevated LDL-C polygenic risk scores have the greatest risk of premature CVD. Genetic testing for FH provides important prognostic information that is independent of LDL-C levels.
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关键词
atherosclerosis,coronary artery disease,genetic testing,LDL,low-density lipoprotein
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