Acetylcholinesterase inhibitors in Alzheimer's disease influence Zinc and Copper homeostasis.
Journal of Trace Elements in Medicine and Biology(2019)
摘要
Our data revealed that AChEI use may affect peripheral Zn and Cu homeostasis in AD patients, decrease Cu/Zn ratio demonstrating a general reduction of inflammatory status in patients under AChEI treatment. Finally, AChEI influence on circulating Zn could be implicated in the drug-related slowdown of cognitive decline.
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关键词
AChEI,AD,ADL,Aβ,CRP,Cu,GDS,IADL,IL10,IL1β,IL6,MMSE,MT2A,NSAIDs,TNFα,Zip2,Zip3,Znt1,Zn
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