LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling

The EMBO journal, 2019.

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Keywords:
HAND2-AS1 BMP signalingINO80 complexcancer stem cellshepatocellular carcinoma

Abstract:

Hepatocellular carcinoma (HCC) is the most prevalent liver cancer, characterized by a high rate of recurrence and heterogeneity. Liver cancer stem cells (CSCs) may well contribute to both of these pathological properties, but the mechanism underlying their self-renewal maintenance is poorly understood. Here, we identified a long noncoding...More

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