Prospective evaluation of host biomarkers other than interferon gamma in QuantiFERON Plus supernatants as candidates for the diagnosis of tuberculosis in symptomatic individuals.

Portia M Manngo,Andrea Gutschmidt,Candice I Snyders,Hygon Mutavhatsindi,Charles M Manyelo,Nonjabulo S Makhoba,Petri Ahlers,Andriette Hiemstra,Kim Stanley,Shirley McAnda,Martin Kidd,Stephanus T Malherbe,Gerhard Walzl,Novel N Chegou

Journal of Infection（2019）

引用 25|浏览17

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摘要

•New tools are urgently needed for the diagnosis of TB.•Biomarkers detected in QuantiFERON Plus supernatants may be useful.•Unstimulated host biomarkers were more promising in this study.•A six-marker unistimulated biosignature showed promise in this study.•Performance of biosignatures may be influenced by HIV infection.

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关键词

Tuberculosis,Biomarker,Sensitivity and specificity,Diagnosis,QuantiFERON

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