Algorithm in the diagnosis of febrile illness using pathogen-specific rapid diagnostic tests.

Simultaneous testing is not appropriate for the diagnosis of AUFIs with presently available tests, which should deter the unsupervised use of multiplex diagnostic tests. The implementation of adaptive algorithms can predict better diagnosis and add value to the available RDTs. The web application of the model can serve as a tool to identify the optimal diagnostic algorithm in different epidemiological settings, whilst taking into account the local epidemiological variables and accuracy of available tests.