A biodegradable poly(amido amine) based on the antimicrobial polymer polyhexamethylene biguanide for efficient and safe gene delivery.

Haonan Xing,Lin Cheng,Mei Lu,Hui Liu,Lang Lang,Tianzhi Yang,Xiaoyun Zhao,Hui Xu,Li Yang,Pingtian Ding

Colloids and Surfaces B: Biointerfaces（2019）

引用 11|浏览7

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摘要

•The first study to design a gene vector by taking advantages from PHMB.•The PHMB-mimicking side chains provide good membrane affinity for the polymer.•The cytotoxicity of the polymer is very low.•The polymer showed a high transfection efficiency in two cell lines.

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关键词

Poly(amido amine),Nonviral gene vector,Gene delivery,Polyhexamethylene biguanide,Biodegradability

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