Research: Theoretical Study of Monoamine Oxidase B Inhibitors as Drug Candidates for Treatment of Parkinson's Disease.

Lucilene R Souza,Leide C S Picanço,Maiara F B Brito, Marcos R S Almeida, Bianca L B Marino,Kessia P A Sousa,Jaderson V Ferreira,Cleydson B S Rodrigues,Guilherme M Silva,Carlos H T P Silva,Carlton A Taft,Lorane I S Hage-Melim

Central nervous system agents in medicinal chemistry（2020）

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摘要

Thus, it is concluded that the proposed modifications led us to satisfactory results, since there was an improvement in toxicological properties of molecules, however, further studies must be carried out to evaluate their biological activities as possible MAO-B inhibitors for PD treatment.

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关键词

Arrhythmias,MAO-B inhibitors,MEP,Mg2+ extrusion,Parkinson',s disease,Pharmacokinetic. toxicological properties,QSAR,adrenergic agonist,cardiac ventricular myocytes,catecholamine,heart,patents,quinidine

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