Effects of pioglitazone on mnemonic hippocampal function: A blood oxygen level-dependent functional magnetic resonance imaging study in elderly adults.

Annchen R Knodt,James R Burke,Kathleen A Welsh-Bohmer,Brenda L Plassman,Daniel K Burns,Stephen K Brannan,Michael Kukulka,Jingtao Wu,Ahmad R Hariri

Alzheimer's & Dementia: Translational Research & Clinical Interventions（2019）

引用 9|浏览30

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摘要

•Right hippocampal activity increased after 7 and 14 days of 0.6 mg of oral pioglitazone administration.•Pioglitazone-associated hippocampal effects were not manifested at the level of memory performance.•Nonspecific increases in distributed brain activity at higher pioglitazone doses (>0.6 mg).

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关键词

Alzheimer's disease,Blood oxygen level–dependent functional magnetic resonance imaging,Mnemonic hippocampal activity,Pioglitazone,Thiazolidinediones

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