Fasudil or genetic depletion of ROCK1 or ROCK2 induces anxiety-like behaviors.

Kelsey M Greathouse,Benjamin W Henderson, Erik G Gentry,Jeremy H Herskowitz

Behavioural Brain Research（2019）

引用 16|浏览8

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摘要

•The clinically approved pan-ROCK inhibitor Fasudil induces anxiety-like behavior.•ROCK1 or ROCK2 heterozygosity induces anxiety-like behavior.•Locomotor activity and working memory is not altered by ROCK1 or ROCK2 heterozygosity.

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关键词

Fasudil,Rho kinase,ROCK1,ROCK2,Anxiety

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