Chemical synthesis of 7α-hydroxycholest-4-en-3-one, a biomarker for irritable bowel syndrome and bile acid malabsorption.

Samuel D Offei,Hadi D Arman,Francis K Yoshimoto

Steroids（2019）

引用 6|浏览3

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摘要

•Multiple transition metal-mediated allylic oxidations at the C3- and C7- positions were explored.•Regioselective C3-oxidation of a C3-desoxy-Δ4-7-oxygenated steroid precursor.•X-ray crystal structure of the title compound (7alpha-hydroxy-cholest-4-en-3-one).

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关键词

Regioselective oxidation,Cytochrome P450,Steroids,Irritable bowel syndrome,Oxysterols

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