Nasal polyps 15-lipoxygenase 1 promotes CCL26/Eotaxin3 expression through ERK activation.

Zhipeng Li,Ming Zeng,Yanhan Deng,Jinming Zhao,Xiuxia Zhou,John B Trudeau,Ezequiel Goldschmidt,John A Moore,Hongwei Chu,Weitian Zhang,Shankai Yin,Zheng Liu,Y Peter Di,Stella E Lee,Sally E Wenzel

Journal of Allergy and Clinical Immunology（2019）

引用 30|浏览39

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摘要

15LO1 is increased in nasal polyp epithelial cells and contributes to CCL26 expression through ERK activation. 15LO1 could be considered a novel therapeutic target for CRSwNP.

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关键词

15-Lipoxygenase 1,CCL26,epithelial cell,nasal polyps,chronic rhinosinusitis,extracellular signal-regulated kinase

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