Cycloartenyl Ferulate and β-Sitosteryl Ferulate - Steryl Ferulates of γ-Oryzanol - Suppress Intracellular Reactive Oxygen Species in Cell-based System.

gamma-Oryzanol is a naturally occurring component of rice bran and consists of various steryl ferulates. The antioxidant activities of gamma-oryzanol have mostly been demonstrated in cell-free systems. Therefore, we determined whether steryl ferulate of gamma-oryzanol suppress spontaneous intracellular reactive oxygen species (ROS) in cell-based systems. We found that cycloartenyl ferulate and beta-sitosteryl ferulate suppressed spontaneous intracellular ROS in a similar way to N-acetylcysteine and alpha-tocopherol.