BAP1 loss is associated with DNA methylomic repatterning in highly aggressive Class 2 uveal melanomas

Clinical cancer research : an official journal of the American Association for Cancer Research, 2019.

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Abstract:

This study, coupled with previous work, suggests that the initial event in the divergence of Class 2 UM from Class 1 UM is loss of one copy of chromosome 3, followed by mutation of on the remaining copy of chromosome 3, leading to the methylomic repatterning profile characteristic of Class 2 UMs.

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