Neuroblastoma in relation to joint effects of vitamin A and maternal and offspring variants in vitamin A-related genes: A report of the Children's Oncology Group.

Angela L Mazul,Clarice R Weinberg,Stephanie M Engel,Anna Maria Siega-Riz,Fei Zou, Kathryn S Carrier,Patricia V Basta,Zalman Vaksman,John M Maris,Sharon J Diskin,Charlene Maxen,Arlene Naranjo,Andrew F Olshan

Cancer Epidemiology（2019）

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摘要

•While vitamin A has biologic plausibility, offspring vitamin A variants are not associated with neuroblastoma.•There may be evidence that maternal variants in Vitamin related genes are associated with neuroblastoma risk.•Maternal vitamin A variants may be modified by maternal vitamin A consumption.

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关键词

Neuroblastoma,Vitamin A,Case-parent triad,Gene-environment interaction

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