Elevations in Circulating sST2 Levels Are Associated With In-hospital Mortality and Adverse Clinical Outcomes After Blunt Trauma.

Isabel M Billiar,Jesse Guardado,Othman Abdul-Malak,Yoram Vodovotz,Timothy R Billiar,Rami A Namas

Journal of Surgical Research（2019）

引用 12|浏览12

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摘要

Elevations in serum sST2 levels are associated with poor clinical trajectories and mortality after blunt trauma. High sST2 coupled with low IL-33 associates with severe injury, mortality, and worse clinical outcomes. These findings suggest that sST2 could serve as an early prognostic biomarker in trauma patients and that sustained elevations of sST2 could contribute to a detrimental suppression of IL-33 bioavailability in patients with high injury severity.

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关键词

Blunt trauma,Acute inflammation,Soluble suppression of tumorigenicity,Intensive care unit,Multiple organ dysfunction syndrome,Base deficit,Coagulopathy,Inflammatory biomarkers,Clinical outcomes,Injury severity

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