mDia1 coordinates mast cell migration and secretion through its actin nucleating activity.

Ofir Klein, Rebecca A Krier-Burris,Pia Lazki-Hagenbach,Yaara Gorzalczany,Yang Mei,Peng Ji,Bruce S Bochner,Ronit Sagi-Eisenberg

Journal of Allergy and Clinical Immunology（2019）

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摘要

Our results demonstrate a unique role of actin rearrangements in clustering the SGs and inhibiting their secretion during MC migration. We identify mDia1 as a novel regulator of MC responses that coordinates MC chemotaxis and secretion through its actin nucleating activity.

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关键词

Mast cells,actin,mammalian diaphanous-related formin 1,chemotaxis,exocytosis

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