Amyloid-beta Impairs Insulin Signaling by Accelerating Autophagy-Lysosomal Degradation of LRP-1 and IR-β in Blood-Brain Barrier Endothelial Cells in Vitro and in 3Xtg-Ad Mice

Chaitanya Chakravarthi Gali,Elham Fanaee-Danesh,Martina Zandl-Lang,Nicole Maria Albrecher,Carmen Tam-Amersdorfer,Anika Stracke,Vinay Sachdev,Florian Reichmann,Yidan Sun,Afrim Avdili, Marielies Reiter,Dagmar Kratky,Peter Holzer,Achim Lass,Karunya K. Kandimalla,Ute Panzenboeck

Molecular and Cellular Neuroscience（2019）

Cited 63|Views66

Key words

Alzheimer's disease,Amyloid-beta peptides,Low-density lipoprotein receptor-related protein-1,Insulin receptor-beta,Insulin signaling,Blood-brain barrier,Endothelial cells,Autophagy-lysosomal pathway

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