Selenocoumarins as new multitarget antiproliferative agents: Synthesis, biological evaluation and in silico calculations.

Irene Lagunes,Paloma Begines, Adrián Silva,Alexis R Galán,Adrián Puerta,Miguel X Fernandes,Inés Maya,José G Fernández-Bolaños,Óscar López,José M Padrón

European Journal of Medicinal Chemistry（2019）

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摘要

Herein we report a straightforward preparation of new antiproliferative agents based on the hybridization of a coumarin skeleton and an organoselenium motif. Three families were obtained: isoselenocyanate, selenocarbamates and selenoureas. The main purpose of these hybrid structures is the development of new antiproliferative agents with a multitarget mode of action.

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关键词

Coumarin,Organoselenium,Antiproliferative,ROS,Multitarget,In silico calculations,Histone deacetylase

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