Susceptibility profiles and clinical efficacy of antifungals against candida bloodstream isolates from critically ill patients: Focus on intravenous itraconazole

Evangelos J. Giamarellos-Bourboulis,Aliki Stamou,Sofia Maraki,Nicky Solomonidi, Eleni Belesiotou,Aikaterini Pistiki,Eleni Antoniadou,Glykeria Vlachogianni,Konstantinos Mandragos,Chronis Tasioudis,Chrisostomos Katsenos,Christina Routsi,George Samonis,George Dimopoulos

International Journal of Antimicrobial Agents（2019）

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摘要

•Itraconazole is superior to other azoles against Candida parapsilosis in vitro.•Itraconazole has a lower fungicidal:inhibitory ratio for C. parapsilosis and Candida glabrata.•Empirical itraconazole was given to critically ill patients who were unresponsive to antimicrobials.•Itraconazole substantially decreased the rate of breakthrough candidemia.

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关键词

Itraconazole,Candida albicans,Candida parapsilosis,Susceptibility

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