Self-management of Epilepsy: A Systematic Review.
Annals of internal medicine(2019)
摘要
Background:Although self-management is recommended for persons with epilepsy, its optimal strategies and effects are uncertain.
Purpose:To evaluate the components and efficacy of self-management interventions in the treatment of epilepsy in community-dwelling persons.
Data Sources:English-language searches of MEDLINE, Cochrane Central Register of Controlled Trials, PsycINFO, and CINAHL in April 2018; the MEDLINE search was updated in March 2019.
Study Selection:Randomized and nonrandomized comparative studies of self-management interventions for adults with epilepsy.
Data Extraction:An investigator assessed study characteristics; intervention details, including 6 components of self-management; and outcomes, which were verified by a second reviewer. Risk of bias (ROB) was assessed independently by 2 investigators.
Data Synthesis:13 randomized and 2 nonrandomized studies (2514 patients) evaluated self-management interventions. Interventions were delivered primarily in group settings, used a median of 4 components, and followed 2 general strategies: 1 based on education and the other on psychosocial therapy. Education-based approaches improved self-management behaviors (standardized mean difference, 0.52 [95% CI, 0.0 to 1.04]), and psychosocial therapy-based approaches improved quality of life (mean difference, 6.64 [CI, 2.51 to 10.77]). Overall, self-management interventions did not reduce seizure rates, but 1 educational intervention decreased a composite of seizures, emergency department visits, and hospitalizations.
Limitation:High ROB in most studies, incomplete intervention descriptions, and studies limited to English-language publications.
Conclusion:There is limited evidence that self-management strategies modestly improve some patient outcomes that are important to persons with epilepsy. Overall, self-management research in epilepsy is limited by the range of interventions tested, the small number of studies using self-monitoring technology, and uncertainty about components and strategies associated with benefit.
Primary Funding Source:U.S. Department of Veterans Affairs. (PROSPERO: CRD42018098604).
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