Chloroquine inhibits endosomal viral RNA release and autophagy-dependent viral replication and effectively prevents maternal to fetal transmission of Zika virus

    Shengnan Zhang
    Shengnan Zhang
    Changhua Yi
    Changhua Yi
    Fan Zhang
    Fan Zhang
    Jiaojiao Peng
    Jiaojiao Peng
    Qian Wang
    Qian Wang
    Xinglong Liu
    Xinglong Liu
    Xianmiao Ye
    Xianmiao Ye
    Min Wu
    Min Wu
    Qihong Yan
    Qihong Yan
    Wenjing Guo
    Wenjing Guo

    Antiviral research, Volume 169, 2019, Pages 104547

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    Keywords:
    AutophagyChloroquineViral RNA releaseZika virus

    Abstract:

    Zika virus (ZIKV) infection can cause neonatal microcephaly and neurological disorders. Currently, there is no designated drug for treating ZIKV infection and preventing neonatal microcephaly. In this study, we evaluated the effect of chloroquine, an anti-malaria drug, in ZIKV infected cells and mouse models. Chloroquine significantly inh...More

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