Prognostic analysis of surgically treated clear cell sarcoma: an analysis of a rare tumor from a single center
International journal of clinical oncology(2019)
摘要
Background The objective of this retrospective study was to evaluate the prognostic value of various factors in clear cell sarcoma patients after radical surgery. Methods Forty-two clear cell sarcoma patients from August 2006 to March 2018 were included in the study. Curves of disease-free survival and overall survival were calculated using the Kaplan–Meier method, and univariate and multivariate analyses of various prognostic factors were performed using a Cox proportional hazard regression model. Laboratory test of peripheral blood was recorded before surgery. The optimal cutoff value of systemic inflammatory markers was defined by receiver-operating curve analysis. Results The 5-year DFS and 5-year OS rate were 22% and 46%, respectively. The median DFS and OS times were 12 and 41.5 months, respectively. In univariate analysis, there was a significant association between shorter DFS and tumor size larger than 5 cm ( p = 0.0043), positive surgical margin ( p = 0.0233), and the neutrophil-to-lymphocyte ratio (NLR) higher than 2.73 ( p = 0.0009). Furthermore, we observed a significant association between shorter OS and tumor size larger than 5 cm ( p = 0.0075), positive surgical margin ( p = 0.0101), NLR higher than 2.73 ( p = 0.0126), the platelet-to-lymphocyte ratio (PLR) higher than 103.89 ( p = 0.0147) and the lymphocyte-to-monocyte ratio (LMR) lower than 4.2 ( p = 0.0445). A multivariate analysis demonstrated that the surgical margin ( p = 0.013) and NLR ( p = 0.001) were significantly associated with DFS. Tumor size ( p = 0.010) and NLR ( p = 0.013) were independent prognostic factors for OS. Conclusions This study had the second largest sample around the world and preoperative NLR may be a useful prognostic factor in CCS patients after radical surgery.
更多查看译文
关键词
Clear cell sarcoma,Rare tumor,Large sample,Inflammatory biomarker,Neutrophil-to-lymphocyte ratio
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要