Methylomic profiles reveal sex-specific differences in leukocyte composition associated with post-traumatic stress disorder.
Brain, Behavior, and Immunity(2019)
摘要
•Higher monocyte proportion is associated with PTSD in males, but not females.•The difference may reflect a long-standing trait of PTSD, rather than current state.•A second cell estimation approach corroborated this sex-specific finding.•Recently developed estimation approaches may improve on previous methods.•This is the first combined study of DNAm-based leukocyte composition in PTSD.
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关键词
PTSD,Monocytes,Leukocyte composition,DNA methylation,Sex differences
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