Si-Miao-Yong-An decoction ameliorates cardiac function through restoring the equilibrium of SOD and NOX2 in heart failure mice

Yinglu Ren
Yinglu Ren
Xiangyang Chen
Xiangyang Chen
Congping Su
Congping Su
Zifan Zeng
Zifan Zeng
Yan Wu
Yan Wu
Xuan Xie
Xuan Xie
Qing Wang
Qing Wang
Shuzhen Guo
Shuzhen Guo

Pharmacological research, Volume 146, 2019, Pages 104318

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Keywords:
Heart failureNOX2Oxidative stressSODSi-Miao-Yong-An Decoction

Abstract:

Si-Miao-Yong-An Decoction (SMYAD), a Chinese herbal formula, has been used in treating ischemic cardiovascular diseases. However, the cardioprotective mechanism of SMYAD treating heart failure (HF) remains unclear. Herein we investigated the effect of SMYAD on isoprenaline (ISO)-induced HF in C57BL/6 mice. Cardiac function and pathologica...More

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