Discovery of novel N-methyl carbazole tethered rhodanine derivatives as direct inhibitors of Mycobacterium tuberculosis InhA.

Bioorganic & Medicinal Chemistry Letters（2019）

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摘要

Synthesis, spectral studies antimycobacterial, InhA enzyme inhibition and cytotoxicity evaluation of novel carbazole hybrid compounds are described.

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关键词

Tuberculosis,InhA inhibitor,Carbazole,Hybridization,GLIDE,Molecular dynamics

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