Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides.
CHEMICAL COMMUNICATIONS(2019)
摘要
Herein, we describe the development of a novel staple with an electrophilic warhead to enable the generation of stapled peptide covalent inhibitors of the p53-MDM2 protein-protein interaction (PPI). The peptide developed showed complete and selective covalent binding resulting in potent inhibition of p53-MDM2 PPI.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络