Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals.

Raymond Noordam,William J Young,Reem Salman,Jørgen K Kanters,Marten E van den Berg,Diana van Heemst,Henry J Lin,Sandhi Maria Barreto,Mary L Biggs,Ginevra Biino,Eulalia Catamo,Maria Pina Concas,Jun Ding,Daniel S Evans,Luisa Foco,Niels Grarup,Leo-Pekka Lyytikäinen,Massimo Mangino,Hao Mei,Peter J van der Most,Martina Müller-Nurasyid,Christopher P Nelson,Yong Qian,Linda Repetto,M Abdullah Said,Nabi Shah,Katharina Schramm,Pedro G Vidigal,Stefan Weiss,Jie Yao,Nuno R Zilhao,Jennifer A Brody,Peter S Braund,Marco Brumat, Eric Campana,Paraskevi Christofidou,Mark J Caulfield,Alessandro De Grandi,Anna F Dominiczak,Alex S F Doney,Gudny Eiriksdottir,Christina Ellervik,Luana Giatti,Martin Gögele,Claus Graff,Xiuqing Guo,Pim van der Harst, Peter K Joshi,Mika Kähönen,Bryan Kestenbaum,Maria F Lima-Costa,Allan Linneberg,Arie C Maan,Thomas Meitinger,Sandosh Padmanabhan,Cristian Pattaro,Annette Peters,Astrid Petersmann,Peter Sever, Mortiz F Sinner,Xia Shen,Alice Stanton,Konstantin Strauch,Elsayed Z Soliman,Kirill V Tarasov,Kent D Taylor,Chris H L Thio,André G Uitterlinden,Simona Vaccargiu,Melanie Waldenberger,Antonietta Robino,Adolfo Correa,Francesco Cucca,Steven R Cummings,Marcus Dörr,Giorgia Girotto,Vilmundur Gudnason,Torben Hansen,Susan R Heckbert,Christian R Juhl,Stefan Kääb,Terho Lehtimäki,Yongmei Liu,Paulo A Lotufo,Colin N A Palmer,Mario Pirastu,Peter P Pramstaller,Antonio Luiz P Ribeiro,Jerome I Rotter,Nilesh J Samani,Harold Snieder,Tim D Spector,Bruno H Stricker,Niek Verweij, James F Wilson, James G Wilson,J Wouter Jukema,Andrew Tinker,Christopher H Newton-Cheh,Nona Sotoodehnia,Dennis O Mook-Kanamori,Patricia B Munroe,Helen R Warren

Journal of the American College of Cardiology（2019）

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摘要

The study identified physiologically relevant associations between electrolytes and electrocardiographic intervals in a large-scale analysis combining cohorts from different settings. The results provide insights for further cardiac electrophysiology research and could potentially influence clinical practice, especially the association between calcium and QT duration, by which calcium levels at the bottom 2% of the population distribution led to clinically relevant QT prolongation by >5 ms.

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关键词

cohort studies,electrocardiographic intervals,electrolytes,epidemiology,meta-analysis

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