First-In-Human Trial Of The Oral Ataxia Telangiectasia And Rad3-Related (Atr) Inhibitor Bay 1895344 In Patients (Pts) With Advanced Solid Tumors.

Johann S. De Bono,David Shao Peng Tan,Reece Caldwell,Angelika Terbuch,Boon C. Goh,Valerie Heong,Noor Md Haris,Saira Bashir,David S. Hong,Funda Meric-Bernstam, Sonal Bordia,Li Liu,Gary Wilkinson,Joseph Hreiki,Antje Wengner,Kerstin Fischer,Oliver Boix,Eleni Lagkadinou,Elizabeth Plummer,Timothy A Yap

JOURNAL OF CLINICAL ONCOLOGY（2019）

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3007Background: The ATR kinase is a key regulator of the DNA damage response (DDR) machinery, activated by DNA damage and replication stress. BAY 1895344 is a novel, potent, and selective ATR inhib...

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