P06-S Temporal lobe connectivity changes during wakefulness and sleep studied through single pulse electrical stimulation

Background Temporal lobe epilepsy is frequently improved after selective resection. However, a small number of these patients have temporal-plus epilepsy and continue seizing. We aim to study the connectivity of the temporal lobe during wakefulness and sleep. Material and methods We included 25 patients with drug-resistant focal epilepsy who had depth electrodes exploration in 2016–2018. We implanted 9–18 electrodes per patient over a large network. We performed single pulse electrical stimulation protocol, as previously described, during wakefulness and sleep. We selected 40,678 statistically significant responses (rho > 0.4, p  Results The difference between the mean responses in all temporal structures between sleep and wakefulness is 10.41 μV (p  Conclusions Temporal lobe connectivity is modulated by sleep, EZ location, and pertainence of certain structures to the EZ, with statistically significant differences between left and right temporal structures.