Engineering the AAV capsid to evade immune responses
Current Opinion in Biotechnology(2019)
摘要
•Innate immune responses to AAV can occur on both short and long timescales.•Conserved epitopes on different AAV serotypes cloak them from NABs when mutated.•A computation-derived shuffling strategy yielded new NAB resistant AAV variants.•AAV capsids have been chemically modified to reduce NAB binding.
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