Circulating tumor DNA detection is correlated to histologic types in patients with early-stage non-small-cell lung cancer

Bin Zhang, Xueliang Niu,Qiang Zhang, Chunli Wang, Bo Liu,Dongsheng Yue,Chenguang Li, Giuseppe Giaccone,Shiyong Li, Liuwei Gao,Hua Zhang, Jian Wang,Huanming Yang,Renhua Wu,Peixiang Ni, Changli Wang,Mingzhi Ye,Weiran Liu

Lung Cancer（2019）

引用 19|浏览66

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摘要

•In early-stage NSCLC, tissue- pre-op plasma concordant ctDNA mutation detection ratio was higher in LUSC than in LUAD.•A LUSC-LUAD classification model was built using LASSO based on ctDNA profiling.•tDNA-ctDNA concordant ratio was associated with gene mutations, histology subtype and tumor size in early-stage NSCLC.

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关键词

Circulating tumor DNA,Next-generation sequencing,Non-small-cell lung cancer,Gene mutations,Classification

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