Mycoplasma infection of cultured cells induces oxidative stress and attenuates cellular base excision repair activity

Yunhee Ji,Mahsa Karbaschi,Marcus S. Cooke

Mutation Research/Genetic Toxicology and Environmental Mutagenesis（2019）

引用 20|浏览4

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摘要

•Mycoplasma infection may be visualized during scoring in the comet assay.•Mycoplasma infection induced oxidative stress and DNA damage.•Mycoplasma impaired base excision repair of oxidised purines, not strand breaks.

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关键词

DNA repair,Base excision repair (BER),8-oxo-7,8-dihydroguanine (8-oxoGua),Cell culture,Reactive oxygen species (ROS),Comet assay,Oxidatively damaged DNA,Oxidative stress,Mycoplasma infection,DNA damage,hOGG1

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