Propofol For Treatment-Resistant Depression: Clinical And Neural Effects

Brian Mickey,Andrew Prescot,Robert Welsh,Perry Renshaw,Scott Tadler

BIOLOGICAL PSYCHIATRY（2019）

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摘要

Propofol is a widely used general anesthetic that engages gamma-aminobutyric acid (GABA) receptors and N-methyl-D-aspartate (NMDA) glutamate receptors. We hypothesized that propofol has antidepressant properties and that it may trigger neuroplasticity by altering excitatory-inhibitory balance in the prefrontal cortex.

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关键词

NMDA Receptor, GABA, Glutamate, Treatment Resistant Depression, Inhibition/Excitation Balance

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