Study on Electronic Determination Method of Conduction Pathway of Rat Primary Motor Cortex Nerve Signals in Spinal Cord

This Spinal cord injury is a type of central nerve injury that permanently changes patients' ability of self-care and quality of life. In recent years, some scholars have attempted to rebuild the lost function due to spinal cord injury through the microelectronic neural bridge. In order to solve the problem of electrode implantation in the microelectronic neural bridge scheme, this study proposed a new method for detecting the conduction pathway of neural signals from rat primary motor cortex in spinal cord with electronic detection technology. Functional electrical stimulation was performed on the primary motor cortex of the rat, and the spinal nerve signals corresponding to the T9-T12 spinal segments were recorded. Correlation and delay between recording sites were analyzed by cross-correlation function to verify whether the neural signals were from the same source, which was the cortex stimulation site. Then the recording sites can be connected to form the conduction pathway. The experiment was carried out on SD rats, and the experimental results were consistent with the expected results, indicating that the method is feasible. And the conduction of rat primary motor cortex nerve signals in spinal cord can be detected from the perspective of electronic informatics. Subsequent experiments can provide practical data for electrode implantation in microelectronic nerve bridging experiments.