Transcriptional Profiling Of Primate Central Nucleus Of The Amygdala Neurons: A Role For Pkcd Neurons In Early Life Anxious Temperament

Children exhibiting stable and extreme anxious temperament (AT) are at risk to develop anxiety and depression. We identified the central nucleus of the amygdala (CeA) as a key player underlying the neural circuity of at-risk children and nonhuman primates with extreme AT. However, the cellular and molecular underpinnings of primate AT are not well understood. Research presented here combines laser capture microscopy (LCM) and RNA-sequencing (RNA-Seq) to characterize AT-related molecular alterations in CeA microcircuits.