PGE2 in fibrosis and cancer: Insights into fibroblast activation

•Fibroblasts are the main cells of connective tissue and participate in wound repair upon activation.•Unchecked fibroblast activation leads to fibrosis and contributes to cancer development.•PGE2 restricts fibroblast activation in fibrosis, thereby acting in an anti-fibrotic manner.•While PGE2 is considered a tumor-promoting lipid, its role in cancer-associated fibroblast activation is unclear.