Design principles of ROS dynamic networks relevant to precision therapies for age-related diseases

The model shows effective ROS-management for a century, followed by a sudden system’s collapse due to the loss of p62 protein. PD related conditions such as lack of DJ-1 protein or increased α-synuclein accelerated the system’s collapse. Various interventions (e.g. addition of antioxidants or caffeine) slowed down the collapse of the system , suggesting the model may help discover new medicinal and nutritional therapies.