Role of Cl− channels in primary brain tumour

Tayyebeh Saberbaghi,Raymond Wong,James T. Rutka,Guan-Lei Wang,Zhong-Ping Feng,Hong-Shuo Sun

Cell Calcium（2019）

引用 16|浏览47

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摘要

•Cl− channel family ClC and CLIC are upregulated in glioma and affect cellular functions.•Synergistic role of Ca2+ and Cl− in glioma– Ca2+ influx enhances ClC-3 activity which induces RVD.•ICl,swell in glioma promotes cell proliferation, migration and invasion via RVD.•Pharmacological Cl− channel inhibitors can potentially have therapeutic effects for glioma treatment.

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关键词

ClC,CLICc,CaCC,KCa,VGCC,TRP,CaMKII,VRAC,RVD,VSOR,ORCC,VSOAC,CFTR,NBD,WHO,GBM,GABA,Icl,RTK,BK,SOCE,CRAC,ER,SR,IP3R,RyR,ATP,STIM1,RPE,Best1,PMC,CLCA,LRRC8A,DCPIB,PLC,CHOP,TNFα,NKCC,MMP,P-gp,DIDS,NPPB,TSA,DIOA,TMZ,Ctx,TEA,MDR,ABC,MRP,MVP,GSC,NSC,CSC,EV

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