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Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage

Amy C. Hart,Lynn Abell, Junqing Guo,Michael E. Mertzman,Ramesh Padmanabha,John E. Macor,Charu Chaudhry,Hao Lu,Kevin O'Malley,Patrick J. Shaw,Carolyn Weigelt,Matthew Pokross,Kevin Kish,Kyoung S. Kim,Lyndon Cornelius,Andrew E. Douglas,Deepa Calambur,Ping Zhang,Brian Carpenter,William J. Pitts

ACS Medicinal Chemistry Letters（2019）

引用 29|浏览65
关键词
RIPK3,type II kinase inhibitor,kinase,structure-based drug design (SBDD),high-throughput screening (HTS),necroptosis
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