Olanzapine exposure diminishes perfusion and decreases volume of sensorimotor cortex in rats

Eva Drazanova,Lucie Kratka,Nadezda Vaskovicova,Radim Skoupy,Katerina Horska,Zuzana Babinska,Hana Kotolova,Lucie Vrlikova,Marcela Buchtova,Zenon Starcuk,Jana Ruda-Kucerova

Pharmacological Reports（2019）

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摘要

•Olanzapine decreased cortical perfusion after acute and chronic olanzapine exposure.•Chronic olanzapine decreased cortical volume.•Suppression of blood perfusion may contribute to later structural impairment.

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关键词

Arterial spin labelling,Cortex,Leptin,Olanzapine,Sprague-Dawley rats

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