Current status of multiscale simulations on GPCRs

Current Opinion in Structural Biology(2019)

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摘要
•GPCRs are key targets for cell signaling and are of great interest to both the pharmaceutical industry and academy.•In this review, recent approaches and applications of multiscale simulations on GPCRs are highlighted.•With increasing number of solved GPCR structures, MD-based hybrid modeling may play a major role in GPCR computations.
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