Thelenota ananas saponin extracts attenuate the atherosclerosis in apoE−/− mice by modulating lipid metabolism

•The antiatherosclerosis effect of T. ananas saponin extracts was firstly discussed.•It reduced aortic plaque size and levels of serum lipid and inflammatory cytokines.•It regulated inflammation and lipid synthesis in the liver and adipose tissue.•It might modulate lipid metabolism by promoting the diversity of intestinal flora.•T. ananas was a beneficial natural resource for the prevention of atherosclerosis.