Towards precise, safe genome editing

Sebastian Memczak,Yanjiao Shao,Juan Carlos Izpisua Belmonte

CELL RESEARCH（2019）

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摘要

Commonly used Cas9:gRNA programmed base-editor complexes introduce frequent, so far unrecognized RNA off-target edits. Novel, engineered enzymes may overcome this hurdle towards clinical applications of genome engineering.

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Life Sciences,general,Cell Biology

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