Overexpression of IL-10 Enhances the Efficacy of Human Umbilical-Cord-Derived Mesenchymal Stromal Cells in E. coli Pneumosepsis

    Mirjana Jerkic
    Mirjana Jerkic
    Lindsay Ormesher
    Lindsay Ormesher
    Stéphane Gagnon
    Stéphane Gagnon
    Sakshi Goyal
    Sakshi Goyal
    Razieh Rabani
    Razieh Rabani

    Journal of clinical medicine, Volume 8, Issue 6, 2019, Pages 847

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    Keywords:
    macrophagemesenchymal stromal cellphagocytosispneumoniasepsis

    Abstract:

    Enhancing the immunomodulatory effects of mesenchymal stromal cells (MSCs) may increase their effects in sepsis. We tested the potential for overexpression of Interleukin-10 (IL-10) in human umbilical cord (UC) MSCs to increase MSC efficacy in pneumosepsis and to enhance human macrophage function. Pneumonia was induced in rats by intrat...More

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