Autism spectrum disorder and neurodevelopmental delays in children with giant omphalocele.

Enrico Danzer,Casey Hoffman,Judith S Miller,Jo Ann D'Agostino,Erica M Schindewolf,Marsha Gerdes,Judy Bernbaum,Samantha E Adams,Natalie E Rintoul,Lisa M Herkert, Lynne Taylor,Jane Schreiber,William H Peranteau,Alan W Flake,N Scott Adzick,Holly L Hedrick

Journal of Pediatric Surgery（2019）

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摘要

There is a significant rate of ASD in GO survivors. Neurodevelopmental delays, language delays, and genetic abnormalities were strongly associated with ASD. Neurological impairments were present in nearly half of GO children. Surrogate markers of disease severity were associated with below average neurodevelopmental scores. Level of evidence Level IV.

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关键词

Giant omphalocele,Autism spectrum disorder,Autism diagnostic observation schedule,Neurodevelopmental delay,Pulmonary hypoplasia,Pulmonary hypertension

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